Drug interactions
Eplerenone + Oxcarbazepine
Severity: Minor
Eplerenone and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak CYP3A4 inducer and may modestly lower eplerenone exposure. The effect may reduce antihypertensive or heart failure benefit in some patients.
What this interaction means in plain words
Eplerenone and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eplerenone belongs to Cardiovascular; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases eplerenone metabolism.
What to do
Monitor blood pressure and clinical response when oxcarbazepine is started or stopped. Increase the eplerenone dose only if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Eplerenone with Oxcarbazepine?
MediHelp rates the interaction as minor. Eplerenone and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine is a weak CYP3A4 inducer and may modestly lower eplerenone exposure. The effect may reduce antihypertensive or heart failure benefit in some patients.
How serious is the interaction between Eplerenone and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response when oxcarbazepine is started or stopped. Increase the eplerenone dose only if response is inadequate.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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