Drug interactions
Eplerenone + Valsartan
Severity: Major
Eplerenone and Valsartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs diminish aldosterone-driven potassium excretion, so combining them raises the risk of hyperkalemia. The risk is greater with renal impairment, diabetes, advanced age or other potassium-raising drugs.
What this interaction means in plain words
Eplerenone and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eplerenone belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone-mediated renal potassium excretion via mineralocorticoid and angiotensin receptor blockade.
What to do
Monitor potassium and renal function at baseline, soon after initiation, and periodically. Reduce or stop eplerenone if hyperkalemia develops and avoid potassium supplements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Eplerenone with Valsartan?
MediHelp rates the interaction as major. Eplerenone and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs diminish aldosterone-driven potassium excretion, so combining them raises the risk of hyperkalemia. The risk is greater with renal impairment, diabetes, advanced age or other potassium-raising drugs.
How serious is the interaction between Eplerenone and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and renal function at baseline, soon after initiation, and periodically. Reduce or stop eplerenone if hyperkalemia develops and avoid potassium supplements.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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