Drug interactions
Epoprostenol + Nabumetone
Severity: Moderate
Epoprostenol and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent inhibitor of platelet aggregation, and nabumetone also impairs platelet function. Used together they may increase the risk of bleeding.
What this interaction means in plain words
Epoprostenol and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive inhibition of platelet aggregation (prostacyclin-mediated cAMP elevation plus NSAID cyclooxygenase inhibition) with NSAID mucosal injury.
What to do
Monitor for bleeding, including gastrointestinal bleeding, and check hemoglobin if symptoms occur. Use a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Nabumetone?
MediHelp rates the interaction as moderate. Epoprostenol and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent inhibitor of platelet aggregation, and nabumetone also impairs platelet function. Used together they may increase the risk of bleeding.
How serious is the interaction between Epoprostenol and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, including gastrointestinal bleeding, and check hemoglobin if symptoms occur. Use a non-NSAID analgesic where possible.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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