Drug interactions
Epoprostenol + Piroxicam
Severity: Moderate
Epoprostenol and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation and piroxicam impairs platelet function, so combined use may increase bleeding risk, including gastrointestinal bleeding.
What this interaction means in plain words
Epoprostenol and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects: prostacyclin-mediated inhibition of platelet aggregation plus NSAID cyclooxygenase inhibition.
What to do
Monitor for signs of bleeding and hemoglobin when used together. Use the lowest NSAID dose for the shortest time or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Piroxicam?
MediHelp rates the interaction as moderate. Epoprostenol and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation and piroxicam impairs platelet function, so combined use may increase bleeding risk, including gastrointestinal bleeding.
How serious is the interaction between Epoprostenol and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and hemoglobin when used together. Use the lowest NSAID dose for the shortest time or choose paracetamol.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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