Drug interactions
Eprosartan + Ethacrynic acid
Severity: Moderate
Eprosartan and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that promotes potassium loss, while eprosartan tends to raise serum potassium. The opposing effects can partly offset each other, but the net effect on potassium is unpredictable. Volume depletion from the diuretic can also increase the risk of hypotension and reduced renal function with an ARB.
What this interaction means in plain words
Eprosartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Opposing effects on potassium (ARB-mediated aldosterone suppression versus loop diuretic kaliuresis) plus additive blood pressure lowering and volume depletion.
What to do
Monitor serum potassium, creatinine and blood pressure after starting or changing doses. Correct volume depletion and adjust the diuretic or ARB dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Eprosartan with Ethacrynic acid?
MediHelp rates the interaction as moderate. Eprosartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that promotes potassium loss, while eprosartan tends to raise serum potassium. The opposing effects can partly offset each other, but the net effect on potassium is unpredictable. Volume depletion from the diuretic can also increase the risk of hypotension and reduced renal function with an ARB.
How serious is the interaction between Eprosartan and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure after starting or changing doses. Correct volume depletion and adjust the diuretic or ARB dose as needed.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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