Drug interactions
Eprosartan + Furosemide
Severity: Moderate
Eprosartan and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide-induced volume depletion can make blood pressure and renal perfusion dependent on angiotensin II, so adding eprosartan may cause hypotension and a decline in renal function. Potassium effects partially offset each other.
What this interaction means in plain words
Eprosartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of volume depletion and angiotensin receptor blockade; opposing effects on potassium.
What to do
Monitor blood pressure, creatinine and potassium after starting or adjusting doses. Consider lowering the diuretic dose if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Furosemide?
MediHelp rates the interaction as moderate. Eprosartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide-induced volume depletion can make blood pressure and renal perfusion dependent on angiotensin II, so adding eprosartan may cause hypotension and a decline in renal function. Potassium effects partially offset each other.
How serious is the interaction between Eprosartan and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting or adjusting doses. Consider lowering the diuretic dose if the patient is volume depleted.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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