Drug interactions
Eprosartan + Gentamicin
Severity: Moderate
Eprosartan and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can reduce renal perfusion and glomerular filtration, particularly with volume depletion, and this may increase exposure to gentamicin and its nephrotoxicity. The potassium effects of the two drugs differ and are not the main concern.
What this interaction means in plain words
Eprosartan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Angiotensin II receptor blockade lowers glomerular filtration pressure, which may reduce aminoglycoside clearance and add to renal injury risk.
What to do
Monitor serum creatinine, potassium and gentamicin levels, and keep the patient well hydrated. Consider temporarily holding the ARB if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Gentamicin?
MediHelp rates the interaction as moderate. Eprosartan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can reduce renal perfusion and glomerular filtration, particularly with volume depletion, and this may increase exposure to gentamicin and its nephrotoxicity. The potassium effects of the two drugs differ and are not the main concern.
How serious is the interaction between Eprosartan and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and gentamicin levels, and keep the patient well hydrated. Consider temporarily holding the ARB if renal function worsens.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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