Drug interactions
Eprosartan + Hydrochlorothiazide-lisinopril
Severity: Major
Eprosartan and Hydrochlorothiazide-lisinopril: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an angiotensin receptor blocker to an ACE inhibitor produces dual renin-angiotensin blockade, with increased risk of hypotension, hyperkalemia and renal impairment without clear added benefit. The thiazide only partly offsets the potassium effect.
What this interaction means in plain words
Eprosartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Dual blockade of the renin-angiotensin-aldosterone system reduces aldosterone and glomerular filtration pressure, causing potassium retention and reduced renal function.
What to do
Avoid combining an ARB with an ACE inhibitor in general. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Eprosartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding an angiotensin receptor blocker to an ACE inhibitor produces dual renin-angiotensin blockade, with increased risk of hypotension, hyperkalemia and renal impairment without clear added benefit. The thiazide only partly offsets the potassium effect.
How serious is the interaction between Eprosartan and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining an ARB with an ACE inhibitor in general. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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