Drug interactions
Eprosartan + Lurasidone
Severity: Moderate
Eprosartan and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with eprosartan, blood pressure lowering may be enhanced, leading to dizziness or falls.
What this interaction means in plain words
Eprosartan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic antagonism and angiotensin receptor blockade.
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation and dose increases. Reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Eprosartan with Lurasidone?
MediHelp rates the interaction as moderate. Eprosartan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with eprosartan, blood pressure lowering may be enhanced, leading to dizziness or falls.
How serious is the interaction between Eprosartan and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation and dose increases. Reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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