Drug interactions
Eprosartan + Trimethoprim
Severity: Major
Eprosartan and Trimethoprim: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce renal potassium excretion, and the combination can cause clinically significant hyperkalemia. The risk is greatest with high trimethoprim doses, renal impairment, diabetes or advanced age.
What this interaction means in plain words
Eprosartan and Trimethoprim can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan belongs to Cardiovascular; Trimethoprim belongs to Anti Bacterial.
Why it happens
Trimethoprim blocks epithelial sodium channels in the distal nephron while ARBs reduce aldosterone effect, together impairing potassium secretion.
What to do
Check serum potassium and creatinine within several days of starting trimethoprim and repeat as needed. Consider an alternative antibiotic in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Trimethoprim
Frequently asked questions
Can I take Eprosartan with Trimethoprim?
MediHelp rates the interaction as major. Eprosartan and Trimethoprim can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs reduce renal potassium excretion, and the combination can cause clinically significant hyperkalemia. The risk is greatest with high trimethoprim doses, renal impairment, diabetes or advanced age.
How serious is the interaction between Eprosartan and Trimethoprim?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine within several days of starting trimethoprim and repeat as needed. Consider an alternative antibiotic in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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