Drug interactions
Eprosartan-hydrochlorothiazide + Furosemide
Severity: Moderate
Eprosartan-hydrochlorothiazide and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding furosemide to a thiazide-ARB combination produces strong sequential diuresis, which can lead to volume depletion, hypotension, electrolyte disturbances and a decline in renal function. Potassium may fall because of both diuretics, although the ARB offsets this partially.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Additive diuretic effects at different nephron sites cause volume and electrolyte depletion, and RAS blockade reduces compensatory glomerular filtration pressure.
What to do
Monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes. Reduce the diuretic dose if volume depletion or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Furosemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Furosemide?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding furosemide to a thiazide-ARB combination produces strong sequential diuresis, which can lead to volume depletion, hypotension, electrolyte disturbances and a decline in renal function. Potassium may fall because of both diuretics, although the ARB offsets this partially.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes. Reduce the diuretic dose if volume depletion or hypotension develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
