Drug interactions
Eprosartan-hydrochlorothiazide + Gentamicin
Severity: Moderate
Eprosartan-hydrochlorothiazide and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin is nephrotoxic and, together with a thiazide and an ARB, volume depletion and altered renal hemodynamics may increase the risk of acute kidney injury and aminoglycoside accumulation. Gentamicin can also cause renal magnesium and potassium wasting, adding to thiazide-induced electrolyte loss.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Aminoglycoside tubular toxicity is compounded by diuretic-induced volume depletion and reduced glomerular perfusion from angiotensin receptor blockade, with additive renal electrolyte losses.
What to do
Monitor serum creatinine, potassium and magnesium, and gentamicin levels where available. Consider temporarily withholding the diuretic and ARB during acute illness or high-dose aminoglycoside therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Gentamicin?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin is nephrotoxic and, together with a thiazide and an ARB, volume depletion and altered renal hemodynamics may increase the risk of acute kidney injury and aminoglycoside accumulation. Gentamicin can also cause renal magnesium and potassium wasting, adding to thiazide-induced electrolyte loss.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium, and gentamicin levels where available. Consider temporarily withholding the diuretic and ARB during acute illness or high-dose aminoglycoside therapy.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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