Drug interactions
Eprosartan-hydrochlorothiazide + Labetalol
Severity: Minor
Eprosartan-hydrochlorothiazide and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol with an ARB and thiazide may cause additive blood pressure lowering, with possible hypotension or dizziness, particularly at initiation. This is a common antihypertensive combination and is usually manageable.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Alpha and beta blockade add to ARB and diuretic-induced vasodilation and volume reduction, producing additive hypotensive effect.
What to do
Monitor blood pressure and heart rate when starting or changing doses and titrate gradually. Avoid in pregnancy because of the ARB component, and take care with potassium in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Labetalol?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labetalol with an ARB and thiazide may cause additive blood pressure lowering, with possible hypotension or dizziness, particularly at initiation. This is a common antihypertensive combination and is usually manageable.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses and titrate gradually. Avoid in pregnancy because of the ARB component, and take care with potassium in renal impairment.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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