Drug interactions
Eprosartan-hydrochlorothiazide + Liraglutide
Severity: Minor
Eprosartan-hydrochlorothiazide and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may worsen glucose control and counteract liraglutide, while the ARB may slightly enhance glucose lowering. Liraglutide-related gastrointestinal losses can also add to the risk of dehydration and kidney injury in patients taking a diuretic and ARB.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Thiazides reduce insulin sensitivity and secretion, ARBs may improve insulin sensitivity, and GLP-1 related vomiting or diarrhea may compound volume depletion.
What to do
Monitor glycemic control when starting or adjusting the thiazide. Advise patients to maintain fluid intake and review the diuretic and ARB if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Liraglutide?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may worsen glucose control and counteract liraglutide, while the ARB may slightly enhance glucose lowering. Liraglutide-related gastrointestinal losses can also add to the risk of dehydration and kidney injury in patients taking a diuretic and ARB.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting or adjusting the thiazide. Advise patients to maintain fluid intake and review the diuretic and ARB if vomiting or diarrhea occurs.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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