Drug interactions
Eprosartan-hydrochlorothiazide + Memantine
Severity: Minor
Eprosartan-hydrochlorothiazide and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated by the kidney partly through tubular secretion, and hydrochlorothiazide may reduce its clearance. Hydrochlorothiazide labeling for memantine notes a possible reduction in thiazide exposure, and the clinical effect is generally minor.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular secretion, plus effects on urine pH and renal clearance.
What to do
No dose change is usually needed. Watch for dizziness, confusion or other memantine adverse effects, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Memantine?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated by the kidney partly through tubular secretion, and hydrochlorothiazide may reduce its clearance. Hydrochlorothiazide labeling for memantine notes a possible reduction in thiazide exposure, and the clinical effect is generally minor.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for dizziness, confusion or other memantine adverse effects, especially in renal impairment.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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