Drug interactions
Eprosartan-hydrochlorothiazide + Metoprolol
Severity: Minor
Eprosartan-hydrochlorothiazide and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers are commonly combined with ARBs and thiazides, and the combination produces additive blood pressure lowering. This may cause excessive hypotension or bradycardia, and thiazides may modestly worsen glucose and lipid effects of beta-blockers.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects through different pathways (beta-blockade, angiotensin receptor blockade and diuresis).
What to do
Monitor blood pressure, heart rate and glucose in diabetic patients when initiating or adjusting doses. No routine change is needed in most patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Metoprolol?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers are commonly combined with ARBs and thiazides, and the combination produces additive blood pressure lowering. This may cause excessive hypotension or bradycardia, and thiazides may modestly worsen glucose and lipid effects of beta-blockers.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and glucose in diabetic patients when initiating or adjusting doses. No routine change is needed in most patients.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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