Drug interactions
Eprosartan-hydrochlorothiazide + Nabumetone
Severity: Moderate
Eprosartan-hydrochlorothiazide and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabumetone may reduce the antihypertensive effect of the eprosartan and hydrochlorothiazide combination. The NSAID, ARB and diuretic together raise the risk of acute kidney injury, particularly in elderly or dehydrated patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion, which is critical when angiotensin II effects are blocked and volume is depleted by the diuretic.
What to do
Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Use the lowest effective dose for the shortest time, or select a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Nabumetone?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabumetone may reduce the antihypertensive effect of the eprosartan and hydrochlorothiazide combination. The NSAID, ARB and diuretic together raise the risk of acute kidney injury, particularly in elderly or dehydrated patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Use the lowest effective dose for the shortest time, or select a non-NSAID analgesic.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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