Drug interactions
Eprosartan-hydrochlorothiazide + Succinylcholine
Severity: Moderate
Eprosartan-hydrochlorothiazide and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-induced electrolyte disturbances may alter neuromuscular blockade, and succinylcholine can transiently raise potassium. The clinical consequences, including arrhythmias or prolonged paralysis, depend on baseline electrolytes.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Potassium and electrolyte shifts from diuretic therapy interact with depolarizing neuromuscular blockade and succinylcholine-induced potassium release.
What to do
Check serum potassium and magnesium before anesthesia and correct abnormalities. Monitor the ECG and neuromuscular function during and after succinylcholine administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Succinylcholine?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-induced electrolyte disturbances may alter neuromuscular blockade, and succinylcholine can transiently raise potassium. The clinical consequences, including arrhythmias or prolonged paralysis, depend on baseline electrolytes.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before anesthesia and correct abnormalities. Monitor the ECG and neuromuscular function during and after succinylcholine administration.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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