Drug interactions
Eprosartan-hydrochlorothiazide + Tizanidine
Severity: Moderate
Eprosartan-hydrochlorothiazide and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is a centrally acting alpha-2 agonist that lowers blood pressure and can cause hypotension, dizziness and bradycardia. Combined with an ARB and thiazide, the hypotensive effect is additive.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism together with angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure, especially during tizanidine initiation and dose titration. Reduce the tizanidine dose or antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Tizanidine?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is a centrally acting alpha-2 agonist that lowers blood pressure and can cause hypotension, dizziness and bradycardia. Combined with an ARB and thiazide, the hypotensive effect is additive.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially during tizanidine initiation and dose titration. Reduce the tizanidine dose or antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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