Drug interactions

Eptifibatide + Rivaroxaban

Severity: Major

Eptifibatide and Rivaroxaban: major interaction.

Last updated 29 Oct 2026 Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Eptifibatide is a glycoprotein IIb/IIIa inhibitor, and combining it with rivaroxaban substantially increases bleeding risk.

What this interaction means in plain words

Eptifibatide and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Eptifibatide belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.

Evidence level: Moderate

Why it happens

Additive hemostatic effects from platelet aggregation blockade and factor Xa inhibition.

What to do

Avoid unless required during acute coronary intervention, and monitor closely for bleeding and hemoglobin. Hold rivaroxaban per local protocol.

What to ask your pharmacist

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

Xarelto - FDA drug label (DailyMed) - section 7 Drug Interactions (class statement: other platelet aggregation inhibitors; "Promptly evaluate any signs or symptoms of blood loss if patients are treated concomitantly with aspirin, other platelet aggregation inhibitors, or NSAIDs") — DailyMed (FDA label)

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Frequently asked questions

Can I take Eptifibatide with Rivaroxaban?

MediHelp rates the interaction as major. Eptifibatide and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eptifibatide is a glycoprotein IIb/IIIa inhibitor, and combining it with rivaroxaban substantially increases bleeding risk.

How serious is the interaction between Eptifibatide and Rivaroxaban?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless required during acute coronary intervention, and monitor closely for bleeding and hemoglobin. Hold rivaroxaban per local protocol.

What other medicines interact with Rivaroxaban?

MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.

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