Drug interactions
Erdafitinib + Fluconazole
Severity: Major
Erdafitinib and Fluconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C9 and CYP3A4, both of which metabolize erdafitinib, and may increase its exposure. This raises the risk of hyperphosphatemia, ocular toxicity, stomatitis and skin or nail effects.
What this interaction means in plain words
Erdafitinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erdafitinib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C9 and CYP3A4 metabolism of erdafitinib by fluconazole.
What to do
Avoid if possible; otherwise monitor closely for erdafitinib adverse reactions and reduce the dose as needed. Consider restoring the dose if fluconazole is stopped and no toxicity is present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Fluconazole?
MediHelp rates the interaction as major. Erdafitinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole inhibits CYP2C9 and CYP3A4, both of which metabolize erdafitinib, and may increase its exposure. This raises the risk of hyperphosphatemia, ocular toxicity, stomatitis and skin or nail effects.
How serious is the interaction between Erdafitinib and Fluconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor closely for erdafitinib adverse reactions and reduce the dose as needed. Consider restoring the dose if fluconazole is stopped and no toxicity is present.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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