Drug interactions
Erdafitinib + Itraconazole
Severity: Major
Erdafitinib and Itraconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase erdafitinib concentrations, which could worsen hyperphosphatemia, ocular toxicity and stomatitis or skin and nail effects.
What this interaction means in plain words
Erdafitinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erdafitinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces erdafitinib metabolism (also CYP2C9 contribution).
What to do
Prefer an alternative antifungal. If coadministration is necessary, monitor closely for adverse reactions and reduce the erdafitinib dose as needed, then reassess after the inhibitor is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Itraconazole?
MediHelp rates the interaction as major. Erdafitinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole may increase erdafitinib concentrations, which could worsen hyperphosphatemia, ocular toxicity and stomatitis or skin and nail effects.
How serious is the interaction between Erdafitinib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antifungal. If coadministration is necessary, monitor closely for adverse reactions and reduce the erdafitinib dose as needed, then reassess after the inhibitor is stopped.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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