Drug interactions
Erdafitinib + Loperamide
Severity: Moderate
Erdafitinib and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may increase loperamide exposure, including in the central nervous system and heart. Higher loperamide levels may cause QT prolongation or CNS effects.
What this interaction means in plain words
Erdafitinib and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Erdafitinib inhibits P-gp efflux of loperamide, increasing its systemic exposure.
What to do
Separate loperamide from erdafitinib by at least 6 hours and keep doses within labeled limits. Monitor for constipation, sedation and cardiac symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Loperamide?
MediHelp rates the interaction as moderate. Erdafitinib and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may increase loperamide exposure, including in the central nervous system and heart. Higher loperamide levels may cause QT prolongation or CNS effects.
How serious is the interaction between Erdafitinib and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate loperamide from erdafitinib by at least 6 hours and keep doses within labeled limits. Monitor for constipation, sedation and cardiac symptoms.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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