Drug interactions
Erdafitinib + Losartan
Severity: Minor
Erdafitinib and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared mainly by CYP2C9, and losartan is a weak CYP2C9 substrate and inhibitor. A clinically meaningful rise in erdafitinib exposure is not expected from this pairing.
What this interaction means in plain words
Erdafitinib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Losartan belongs to Cardiovascular.
Why it happens
Possible weak competitive CYP2C9 inhibition by losartan; it is not a strong inhibitor.
What to do
No dose change is needed; monitor for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Losartan?
MediHelp rates the interaction as minor. Erdafitinib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is cleared mainly by CYP2C9, and losartan is a weak CYP2C9 substrate and inhibitor. A clinically meaningful rise in erdafitinib exposure is not expected from this pairing.
How serious is the interaction between Erdafitinib and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity as usual.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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