Drug interactions
Erdafitinib + Lovastatin
Severity: Moderate
Erdafitinib and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-gp and may modestly raise lovastatin exposure. The clinical impact is uncertain, but higher statin levels may increase muscle toxicity.
What this interaction means in plain words
Erdafitinib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Lovastatin belongs to Cardiovascular.
Why it happens
P-gp inhibition by erdafitinib reduces efflux of lovastatin.
What to do
Separate dosing by at least 6 hours, as advised for P-gp substrates, and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Lovastatin?
MediHelp rates the interaction as moderate. Erdafitinib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-gp and may modestly raise lovastatin exposure. The clinical impact is uncertain, but higher statin levels may increase muscle toxicity.
How serious is the interaction between Erdafitinib and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing by at least 6 hours, as advised for P-gp substrates, and monitor for muscle symptoms.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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