Drug interactions
Erdafitinib + Mefenamic acid
Severity: Moderate
Erdafitinib and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared mainly by CYP2C9 and CYP3A4, and mefenamic acid is a CYP2C9 substrate and inhibitor of modest potency. Higher erdafitinib exposure could increase adverse effects such as hyperphosphatemia, ocular toxicity, stomatitis and skin or nail disorders.
What this interaction means in plain words
Erdafitinib and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated erdafitinib metabolism by mefenamic acid may raise erdafitinib plasma concentrations.
What to do
Prefer a different analgesic. If the combination is needed, monitor for erdafitinib toxicity such as serum phosphate, eye and skin effects and reduce the dose if adverse reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Mefenamic acid?
MediHelp rates the interaction as moderate. Erdafitinib and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib is cleared mainly by CYP2C9 and CYP3A4, and mefenamic acid is a CYP2C9 substrate and inhibitor of modest potency. Higher erdafitinib exposure could increase adverse effects such as hyperphosphatemia, ocular toxicity, stomatitis and skin or nail disorders.
How serious is the interaction between Erdafitinib and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different analgesic. If the combination is needed, monitor for erdafitinib toxicity such as serum phosphate, eye and skin effects and reduce the dose if adverse reactions occur.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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