Drug interactions
Erdafitinib + Memantine
Severity: Minor
Erdafitinib and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib may inhibit OCT2-mediated renal secretion of memantine, which could raise memantine levels. Higher exposure may cause dizziness, confusion and other CNS effects.
What this interaction means in plain words
Erdafitinib and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Memantine belongs to Central Nervous System.
Why it happens
Inhibition of renal tubular OCT2 transport reduces memantine renal clearance.
What to do
Watch for dizziness, confusion or agitation, and lower the memantine dose if these appear, particularly in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erdafitinib and Memantine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Memantine?
MediHelp rates the interaction as minor. Erdafitinib and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib may inhibit OCT2-mediated renal secretion of memantine, which could raise memantine levels. Higher exposure may cause dizziness, confusion and other CNS effects.
How serious is the interaction between Erdafitinib and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for dizziness, confusion or agitation, and lower the memantine dose if these appear, particularly in patients with renal impairment.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
