Drug interactions
Erdafitinib + Omeprazole
Severity: Minor
Erdafitinib and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is metabolised by CYP2C9 and CYP3A4. Omeprazole is not a strong CYP2C9 inhibitor, so a clinically relevant rise in erdafitinib exposure is unlikely.
What this interaction means in plain words
Erdafitinib and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak, non-significant CYP2C9 effect from omeprazole.
What to do
No dose adjustment is needed. Monitor for usual erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Omeprazole?
MediHelp rates the interaction as minor. Erdafitinib and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is metabolised by CYP2C9 and CYP3A4. Omeprazole is not a strong CYP2C9 inhibitor, so a clinically relevant rise in erdafitinib exposure is unlikely.
How serious is the interaction between Erdafitinib and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for usual erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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