Drug interactions
Erdafitinib + Oxaliplatin
Severity: Moderate
Erdafitinib and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits the renal transporter OCT2, which contributes to oxaliplatin uptake and elimination. Co-administration might raise oxaliplatin exposure and toxicity, though clinical data are limited.
What this interaction means in plain words
Erdafitinib and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Inhibition of OCT2-mediated renal transport reduces oxaliplatin clearance.
What to do
Monitor for increased oxaliplatin toxicity, including neuropathy and myelosuppression. Consider dose reduction of oxaliplatin based on tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Oxaliplatin?
MediHelp rates the interaction as moderate. Erdafitinib and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits the renal transporter OCT2, which contributes to oxaliplatin uptake and elimination. Co-administration might raise oxaliplatin exposure and toxicity, though clinical data are limited.
How serious is the interaction between Erdafitinib and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased oxaliplatin toxicity, including neuropathy and myelosuppression. Consider dose reduction of oxaliplatin based on tolerability.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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