Drug interactions
Erdafitinib + Paliperidone
Severity: Moderate
Erdafitinib and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib may inhibit P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may increase. This could raise dose-related adverse effects such as QT prolongation and extrapyramidal symptoms.
What this interaction means in plain words
Erdafitinib and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Paliperidone belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux of paliperidone by erdafitinib.
What to do
Separate paliperidone and erdafitinib dosing by at least 6 hours where an oral paliperidone formulation is used. Monitor for paliperidone adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Paliperidone?
MediHelp rates the interaction as moderate. Erdafitinib and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib may inhibit P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may increase. This could raise dose-related adverse effects such as QT prolongation and extrapyramidal symptoms.
How serious is the interaction between Erdafitinib and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate paliperidone and erdafitinib dosing by at least 6 hours where an oral paliperidone formulation is used. Monitor for paliperidone adverse effects.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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