Drug interactions
Erdafitinib + Piroxicam
Severity: Minor
Erdafitinib and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is partly metabolized by CYP2C9, and strong CYP2C9 inhibitors can raise its exposure and the risk of adverse effects such as hyperphosphatemia and ocular or skin toxicity. Piroxicam is a CYP2C9 substrate rather than a strong inhibitor, so a meaningful interaction is not established.
What this interaction means in plain words
Erdafitinib and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Piroxicam belongs to Musculoskeletal.
Why it happens
Piroxicam is metabolized by CYP2C9 and is not a recognized strong inhibitor, so any competition at CYP2C9 is unlikely to be clinically significant.
What to do
No dose change is generally needed. Monitor for erdafitinib adverse reactions as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Piroxicam?
MediHelp rates the interaction as minor. Erdafitinib and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is partly metabolized by CYP2C9, and strong CYP2C9 inhibitors can raise its exposure and the risk of adverse effects such as hyperphosphatemia and ocular or skin toxicity. Piroxicam is a CYP2C9 substrate rather than a strong inhibitor, so a meaningful interaction is not established.
How serious is the interaction between Erdafitinib and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for erdafitinib adverse reactions as routine.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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