Drug interactions
Erdafitinib + Ribociclib
Severity: Moderate
Erdafitinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase erdafitinib concentrations, raising the risk of hyperphosphatemia, ocular and skin toxicity.
What this interaction means in plain words
Erdafitinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing erdafitinib metabolism.
What to do
Monitor for erdafitinib toxicity such as hyperphosphatemia and eye symptoms, and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Ribociclib?
MediHelp rates the interaction as moderate. Erdafitinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may increase erdafitinib concentrations, raising the risk of hyperphosphatemia, ocular and skin toxicity.
How serious is the interaction between Erdafitinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib toxicity such as hyperphosphatemia and eye symptoms, and reduce the dose if adverse effects emerge.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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