Drug interactions
Erdafitinib + Sirolimus
Severity: Major
Erdafitinib and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is a P-glycoprotein inhibitor and a weak CYP3A4 modulator, so it may increase sirolimus concentrations and the risk of sirolimus toxicity. Sirolimus has a narrow therapeutic range, so the effect can matter clinically.
What this interaction means in plain words
Erdafitinib and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erdafitinib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Erdafitinib inhibits intestinal P-glycoprotein efflux of sirolimus and may also alter CYP3A4 activity.
What to do
Where possible choose an alternative. If both must be given, separate sirolimus from erdafitinib by at least 6 hours and monitor sirolimus trough concentrations and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Sirolimus?
MediHelp rates the interaction as major. Erdafitinib and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib is a P-glycoprotein inhibitor and a weak CYP3A4 modulator, so it may increase sirolimus concentrations and the risk of sirolimus toxicity. Sirolimus has a narrow therapeutic range, so the effect can matter clinically.
How serious is the interaction between Erdafitinib and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative. If both must be given, separate sirolimus from erdafitinib by at least 6 hours and monitor sirolimus trough concentrations and adverse effects.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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