Drug interactions
Ergoloid mesylates + Midodrine
Severity: Moderate
Ergoloid mesylates and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates are ergot derivatives with weak vasoactive properties, and midodrine is a vasopressor. Combining them could theoretically add to pressor effects, but the vasoconstrictor activity of ergoloids is much weaker than that of other ergots.
What this interaction means in plain words
Ergoloid mesylates and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive vasopressor effects; ergoloids have little vasoconstrictor activity so the interaction is largely theoretical.
What to do
Monitor blood pressure, including supine readings, when starting or adjusting either drug. Reduce midodrine dose if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Ergoloid mesylates with Midodrine?
MediHelp rates the interaction as moderate. Ergoloid mesylates and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergoloid mesylates are ergot derivatives with weak vasoactive properties, and midodrine is a vasopressor. Combining them could theoretically add to pressor effects, but the vasoconstrictor activity of ergoloids is much weaker than that of other ergots.
How serious is the interaction between Ergoloid mesylates and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, when starting or adjusting either drug. Reduce midodrine dose if hypertension develops.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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