Drug interactions
Ergotamine + Fosphenytoin
Severity: Minor
Ergotamine and Fosphenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, a CYP3A4 inducer, which may lower ergotamine concentrations and reduce its effect. No harmful toxicity is expected from this mechanism.
What this interaction means in plain words
Ergotamine and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing ergotamine clearance.
What to do
Monitor for reduced migraine response and adjust therapy if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Ergotamine with Fosphenytoin?
MediHelp rates the interaction as minor. Ergotamine and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosphenytoin is converted to phenytoin, a CYP3A4 inducer, which may lower ergotamine concentrations and reduce its effect. No harmful toxicity is expected from this mechanism.
How serious is the interaction between Ergotamine and Fosphenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine response and adjust therapy if efficacy is lost.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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