Drug interactions
Ergotamine + Hydrocortisone
Severity: Minor
Ergotamine and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is not a meaningful CYP3A4 inducer at usual doses, so a clinically significant reduction in ergotamine exposure is not expected. The concern is theoretical.
What this interaction means in plain words
Ergotamine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Hydrocortisone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 induction by hydrocortisone; not established clinically.
What to do
No dose change is needed; monitor headache response during prolonged high-dose corticosteroid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Hydrocortisone?
MediHelp rates the interaction as minor. Ergotamine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is not a meaningful CYP3A4 inducer at usual doses, so a clinically significant reduction in ergotamine exposure is not expected. The concern is theoretical.
How serious is the interaction between Ergotamine and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor headache response during prolonged high-dose corticosteroid therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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