Drug interactions
Ergotamine + Lsd
Severity: Moderate
Ergotamine and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonin receptor agonist, and ergotamine has overlapping receptor activity and vasoconstrictive effects. Combining them could amplify vasoconstriction and serotonergic effects, though data are limited.
What this interaction means in plain words
Ergotamine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive agonism at serotonin receptors, with possible additive vasoconstriction.
What to do
Avoid ergotamine use around LSD exposure where possible. Monitor for hypertension, limb ischemia and serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Lsd?
MediHelp rates the interaction as moderate. Ergotamine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a potent serotonin receptor agonist, and ergotamine has overlapping receptor activity and vasoconstrictive effects. Combining them could amplify vasoconstriction and serotonergic effects, though data are limited.
How serious is the interaction between Ergotamine and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ergotamine use around LSD exposure where possible. Monitor for hypertension, limb ischemia and serotonin toxicity.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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