Drug interactions
Ergotamine + Miconazole vaginal
Severity: Moderate
Ergotamine and Miconazole vaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has limited systemic absorption, so a clinically significant rise in ergotamine exposure is uncommon, though some systemic absorption and CYP3A4 inhibition is possible. The contraindication applies chiefly to systemic azoles.
What this interaction means in plain words
Ergotamine and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 inhibition by absorbed miconazole reducing ergotamine clearance.
What to do
Consider a short-course alternative non-azole antifungal if ergotamine is needed, and monitor for numbness, tingling or cold extremities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Miconazole vaginal?
MediHelp rates the interaction as moderate. Ergotamine and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vaginal miconazole has limited systemic absorption, so a clinically significant rise in ergotamine exposure is uncommon, though some systemic absorption and CYP3A4 inhibition is possible. The contraindication applies chiefly to systemic azoles.
How serious is the interaction between Ergotamine and Miconazole vaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a short-course alternative non-azole antifungal if ergotamine is needed, and monitor for numbness, tingling or cold extremities.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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