Drug interactions
Ergotamine + Midazolam intranasal
Severity: Minor
Ergotamine and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is a weak CYP3A4 inhibitor and may slightly raise midazolam exposure. This may prolong sedation after the intranasal dose.
What this interaction means in plain words
Ergotamine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by ergotamine reduces midazolam metabolism.
What to do
Observe the patient for prolonged sedation and respiratory depression after the midazolam dose. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Midazolam intranasal?
MediHelp rates the interaction as minor. Ergotamine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotamine is a weak CYP3A4 inhibitor and may slightly raise midazolam exposure. This may prolong sedation after the intranasal dose.
How serious is the interaction between Ergotamine and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe the patient for prolonged sedation and respiratory depression after the midazolam dose. No dose change is usually required.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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