Drug interactions
Ergotamine + Mobocertinib
Severity: Moderate
Ergotamine and Mobocertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is a moderate CYP3A inducer and may lower ergotamine concentrations, reducing efficacy. It is also a QT-prolonging drug, but the main concern is loss of antimigraine effect.
What this interaction means in plain words
Ergotamine and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mobocertinib induces CYP3A4, increasing ergotamine clearance.
What to do
Monitor for reduced migraine control and consider an alternative therapy. Avoid raising the ergotamine dose beyond labeled maximums.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Mobocertinib?
MediHelp rates the interaction as moderate. Ergotamine and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mobocertinib is a moderate CYP3A inducer and may lower ergotamine concentrations, reducing efficacy. It is also a QT-prolonging drug, but the main concern is loss of antimigraine effect.
How serious is the interaction between Ergotamine and Mobocertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine control and consider an alternative therapy. Avoid raising the ergotamine dose beyond labeled maximums.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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