Drug interactions
Ergotamine + Molindone
Severity: Minor
Ergotamine and Molindone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonergic and dopaminergic pathways, so additive effects are theoretically possible. Evidence for a clinically significant interaction is limited.
What this interaction means in plain words
Ergotamine and Molindone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic and dopaminergic effects; the mechanism is not well established.
What to do
Monitor for features of serotonin toxicity or neuroleptic malignant syndrome, such as hyperthermia, rigidity and mental status change. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Molindone?
MediHelp rates the interaction as minor. Ergotamine and Molindone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on serotonergic and dopaminergic pathways, so additive effects are theoretically possible. Evidence for a clinically significant interaction is limited.
How serious is the interaction between Ergotamine and Molindone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin toxicity or neuroleptic malignant syndrome, such as hyperthermia, rigidity and mental status change. No routine dose adjustment is needed.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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