Drug interactions
Ergotamine + Nefazodone
Severity: Contraindicated
Ergotamine and Nefazodone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and can sharply increase ergotamine exposure, risking serious vasospasm and ischemia. Ergotamine labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Ergotamine and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nefazodone strongly inhibits CYP3A4, markedly reducing ergotamine metabolism.
What to do
Do not co-administer; use a non-ergot migraine therapy during nefazodone treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergotamine and Nefazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Nefazodone?
MediHelp rates the interaction as contraindicated. Ergotamine and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone is a potent CYP3A4 inhibitor and can sharply increase ergotamine exposure, risking serious vasospasm and ischemia. Ergotamine labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Ergotamine and Nefazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-ergot migraine therapy during nefazodone treatment.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
