Drug interactions
Ergotamine + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Contraindicated
Ergotamine and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The ritonavir-boosted regimen strongly inhibits CYP3A4 and greatly increases ergotamine exposure. This can cause acute ergot toxicity with vasospasm and tissue ischemia.
What this interaction means in plain words
Ergotamine and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Ritonavir and paritaprevir inhibit CYP3A4, impairing ergotamine metabolism.
What to do
Do not co-administer; use a non-ergot migraine therapy throughout the antiviral course.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Ergotamine and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The ritonavir-boosted regimen strongly inhibits CYP3A4 and greatly increases ergotamine exposure. This can cause acute ergot toxicity with vasospasm and tissue ischemia.
How serious is the interaction between Ergotamine and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-ergot migraine therapy throughout the antiviral course.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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