Drug interactions
Ergotamine + Phendimetrazine
Severity: Major
Ergotamine and Phendimetrazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that raises blood pressure, and combined with ergotamine's vasoconstriction it may cause hypertension and vasospasm.
What this interaction means in plain words
Ergotamine and Phendimetrazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic vasoconstrictor and pressor effects.
What to do
Avoid the combination; use a non-sympathomimetic weight management option or a different migraine therapy. Monitor blood pressure if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Phendimetrazine?
MediHelp rates the interaction as major. Ergotamine and Phendimetrazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phendimetrazine is a sympathomimetic anorectic that raises blood pressure, and combined with ergotamine's vasoconstriction it may cause hypertension and vasospasm.
How serious is the interaction between Ergotamine and Phendimetrazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-sympathomimetic weight management option or a different migraine therapy. Monitor blood pressure if unavoidable.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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