Drug interactions
Ergotamine + Pimozide
Severity: Minor
Ergotamine and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is a potent CYP3A4 substrate and its toxicity is increased by CYP3A4 inhibitors, but pimozide is not a meaningful inhibitor of this enzyme. Any interaction is largely theoretical, although both drugs are used by patients who may also take other interacting agents. Ergotamine can cause vasoconstriction and has been linked to serotonergic effects.
What this interaction means in plain words
Ergotamine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; theoretical pharmacodynamic overlap.
What to do
No routine change is needed, but check the patient's full list for CYP3A4 inhibitors that would affect ergotamine. Monitor for peripheral ischemia or serotonin toxicity symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Pimozide?
MediHelp rates the interaction as minor. Ergotamine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotamine is a potent CYP3A4 substrate and its toxicity is increased by CYP3A4 inhibitors, but pimozide is not a meaningful inhibitor of this enzyme. Any interaction is largely theoretical, although both drugs are used by patients who may also take other interacting agents. Ergotamine can cause vasoconstriction and has been linked to serotonergic effects.
How serious is the interaction between Ergotamine and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed, but check the patient's full list for CYP3A4 inhibitors that would affect ergotamine. Monitor for peripheral ischemia or serotonin toxicity symptoms.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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