Drug interactions
Ergotamine + Quinupristin / dalfopristin
Severity: Major
Ergotamine and Quinupristin / dalfopristin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase ergotamine concentrations, risking ergotism with vasospasm and ischemia. The combination should be avoided given ergotamine's narrow safety margin.
What this interaction means in plain words
Ergotamine and Quinupristin / dalfopristin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing ergotamine metabolism.
What to do
Avoid concurrent use and withhold ergotamine during therapy. If exposure occurs, monitor for peripheral ischemia and paresthesias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergotamine and Quinupristin / dalfopristin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Quinupristin / dalfopristin?
MediHelp rates the interaction as major. Ergotamine and Quinupristin / dalfopristin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinupristin/dalfopristin inhibits CYP3A4 and may increase ergotamine concentrations, risking ergotism with vasospasm and ischemia. The combination should be avoided given ergotamine's narrow safety margin.
How serious is the interaction between Ergotamine and Quinupristin / dalfopristin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and withhold ergotamine during therapy. If exposure occurs, monitor for peripheral ischemia and paresthesias.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
