Drug interactions
Ergotamine + Ropeginterferon alfa 2b
Severity: Moderate
Ergotamine and Ropeginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can suppress CYP450 activity through inflammatory cytokine effects and may raise concentrations of CYP3A4 substrates. This could increase ergotamine exposure and the risk of ergotism.
What this interaction means in plain words
Ergotamine and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Interferon-mediated downregulation of CYP450 enzymes reduces ergotamine clearance.
What to do
Monitor for symptoms of ergotism such as paresthesia, cold extremities and nausea. Use the lowest effective ergotamine dose or choose an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Ropeginterferon alfa 2b?
MediHelp rates the interaction as moderate. Ergotamine and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can suppress CYP450 activity through inflammatory cytokine effects and may raise concentrations of CYP3A4 substrates. This could increase ergotamine exposure and the risk of ergotism.
How serious is the interaction between Ergotamine and Ropeginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of ergotism such as paresthesia, cold extremities and nausea. Use the lowest effective ergotamine dose or choose an alternative.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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