Drug interactions
Ergotamine + Same
Severity: Minor
Ergotamine and Same: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) has serotonergic activity, and ergotamine acts at serotonin receptors, so additive effects are theoretically possible. Clinical evidence of a significant interaction is lacking.
What this interaction means in plain words
Ergotamine and Same have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic effects; the mechanism is not well established.
What to do
Monitor for agitation, tremor, diarrhea or hyperthermia. Stop SAMe if serotonergic symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Same?
MediHelp rates the interaction as minor. Ergotamine and Same have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. S-adenosylmethionine (SAMe) has serotonergic activity, and ergotamine acts at serotonin receptors, so additive effects are theoretically possible. Clinical evidence of a significant interaction is lacking.
How serious is the interaction between Ergotamine and Same?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, diarrhea or hyperthermia. Stop SAMe if serotonergic symptoms develop.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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