Drug interactions
Ergotamine + Selegiline transdermal
Severity: Major
Ergotamine and Selegiline transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor with serotonergic activity, and ergotamine acts on serotonin receptors. Together they may increase the risk of serotonin syndrome and hypertensive effects, although transdermal use gives lower gut MAO-A inhibition.
What this interaction means in plain words
Ergotamine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic and pressor effects from MAO inhibition combined with ergot receptor agonism.
What to do
Avoid the combination where possible. If used, monitor blood pressure and for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Selegiline transdermal?
MediHelp rates the interaction as major. Ergotamine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline is an MAO inhibitor with serotonergic activity, and ergotamine acts on serotonin receptors. Together they may increase the risk of serotonin syndrome and hypertensive effects, although transdermal use gives lower gut MAO-A inhibition.
How serious is the interaction between Ergotamine and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor blood pressure and for serotonin toxicity.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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