Drug interactions
Ergotamine + Sofosbuvir / velpatasvir
Severity: Moderate
Ergotamine and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir is a weak inhibitor of CYP3A4 and may modestly increase ergotamine concentrations. Because ergotamine has a narrow margin and high levels cause severe vasospasm, even a small rise matters.
What this interaction means in plain words
Ergotamine and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak inhibition of CYP3A4 by velpatasvir reduces ergotamine clearance.
What to do
Monitor for signs of ergotism such as limb coldness, paresthesia and chest pain during the antiviral course. Consider an alternative migraine therapy during treatment if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Ergotamine and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir is a weak inhibitor of CYP3A4 and may modestly increase ergotamine concentrations. Because ergotamine has a narrow margin and high levels cause severe vasospasm, even a small rise matters.
How serious is the interaction between Ergotamine and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of ergotism such as limb coldness, paresthesia and chest pain during the antiviral course. Consider an alternative migraine therapy during treatment if possible.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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